BACKGROUND: In 2022, the WHO recommended the 6-month regimens BPaL (bedaquiline + pretomanid + linezolid) and BPaLM (BPaL + moxifloxacin) as treatment options for most forms of drug-resistant TB.SLASH-TB estimates the cost-saving and cost-effectiveness for the healthcare system and patients when a country switches from sapatilha infantil prata glit
Cells of the spinal cord and somites arise from shared, dual-fated precursors, located towards the posterior of the elongating embryo.Here we show that these neuromesodermal progenitors (NMPs) can readily be generated in vitro from mouse and human pluripotent stem cells by activating Wnt and Fgf signalling, timed to emulate in vivo development.Simi
Dynamic regulation of gene expression via signal transduction pathways is of fundamental importance during many biological processes such as cell state transitioning, cell cycle progression and stress responses.In this study we used serum stimulation as a cell response paradigm to apply the nascent RNA Bru-seq technique in order to capture early dy
BACKGROUND:The freshwater planarian tonic shower cap Dugesia japonica (D.japonica) possesses extraordinary ability to regenerate lost organs or body parts.Interestingly, in the process of regeneration, there is little wound infection, suggesting that D.japonica has a formidable innate immune system.The importance of immune system prompted us to sea
Contracts for oil and gas development projects are naturally complex, they are explained with some of maps and technical specifications.To supply the goals of contracts, it is necessary to construct by a team having owner, consulting engineer and contractor.The unique aspects of each project and team working are resulting to disagreements.It should